The ending of the first film is shown, but extended to reveal how the demon possessed Ángela, who went into hiding as Owen and the GEO team broke into the penthouse earlier in the film. When asked how the woman survived, the demonic Ángela looks at the camera and smiles. She also tells them that he is staying behind because he is infected and the only survivor is a woman, Ángela. She takes his radio and, using Owen's voice, says that the mission is over and that they can let them out. After telling Owen that she does not need him to get out as she can impersonate his voice, she kills him. It is then revealed that Tristana has possessed Ángela, so she can leave the darkness she was trapped in, and consequently the building.
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Rosso tells her to stop, but she shoots and kills him. When Owen refuses to authorize their exit, Ángela starts to beat him to force him to do so. At this point, the only survivors left are Ángela, Owen, and Rosso (Pablo Rosso), a GEO officer. Owen is enraged because he needed the blood sample, but all Ángela wants to do is leave the building. After Owen's radio starts producing noises, Tristana attacks them and after some struggling, Ángela blows her head off with a shotgun. They turn the lights off again and try to remain silent not to alarm Tristana. They turn the lights on only to witness that he and Tristana had disappeared. While Fernandez investigates it, Tristana leaps out of the water and drags him in. They find a tub filled with water that cannot be seen when the lights are on. When they turn on the camera's night vision, a door appears that leads them to a room. Owen deduces that some things can only be seen in the dark. When Ángela is asked how she saw Tristana, she says she saw her through the camera's night vision. The demon then gives a hint that the "light" blinds them from seeing the path. The GEO team leader argues that they had already cleared that area and did not see anything.
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The demon possessing Tito tells him that she is "in the highest." Owen figures out that this means that she is in the penthouse. Owen then forces Tito to tell him where Tristana Medeiros is. Then the group finds Ángela Vidal (Manuela Velasco), the reporter from REC, who still has her camera with her. Tito gets bitten by the infected, and they restrain him and lock Mire and Ori in a room. Inside, the teenagers find Jennifer's father and the firefighter they attempt to leave the building through the sewage system only to find it sealed, much to the dismay of the firefighter.Īfter some deaths from attacks by the possessed, the two groups find each other. The teenagers gain access to the building through the sewage system however, police have seen them and seal their exit. When the police seal off the building, they find them and escort them out to the street. Moments before the building is quarantined, three teenagers named Tito (Pau Poch), Mire (Andrea Ros) and Ori are messing around on a roof.
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Jennifer's father (Pep Molina), who was outside getting medicine for his daughter (the infected Jennifer from the first installment), manages to convince a firefighter to take him into the building. Owen tells them that they must get a blood sample from Tristana herself. Owen then performs a religious rite, and the blood spontaneously combusts, confirming that it is the blood he's looking for however, the rest of the blood also sets on fire and Fernandez, commanding officer of the GEO team drops it, rendering it useless. Larra (Ariel Casas), one of the GEO officers, goes into the air duct and finds a sample of her blood – the only one that the original priest took from her. When they get to the penthouse, they find out that the infected can travel all around the building through the air ducts. It turns out that Owen is actually a priest sent by the Vatican to get a blood sample from a possessed girl named Tristana Medeiros and aid the other priest in charge of her.
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After encountering some of the infected, Owen uses religious mantra and rosary to fight them off. Owen (Jonathan Mellor), an official from the Ministry of Health, and a GEO team equipped with helmet-mounted video cameras are sent into a quarantined apartment building to control the situation.